The spread of the new coronavirus (COVID-19) epidemic has affected the order of human life, changed the implementation mode of school education, and blocked the pattern and pace of global school education, changed the established mode of school management, and disrupted school curricula and teaching The design and implementation of the system revise the educational viewpoints of school educators. Due to the epidemic situation, the school education implementation model and curriculum teaching practice have a new model and new development. Major countries in the world, including Taiwan, the United States, the United Kingdom, France, and China, are facing the development of the epidemic, implementing various response strategies and changing the original school education model to maintain the original school education effectiveness. The main purpose of this article is to explore the school education implementation model and its enlightenment during the epidemic in major countries, and through cross-country analysis and comparative research, propose the new school education implementation model and enlightenment, and provide advise for academic and practical circles.