放射治療危及器官之有效劑量及預後是放射腫瘤科醫師和醫學物理師長期關注的問題。本研究使用6MV、10MV直線加速器之強度調控放射治療技術改變治療角度與弧形調控放射治療技術改變圈數來模擬攝護腺癌病人治療過程及劑量分佈比較。光激發光劑量計進行攝護腺癌鄰近器官劑量評估與驗證。強度調控放射治療技術與弧形調控治療技術獲得相似的劑量分佈，弧形調控治療技術改善劑量分佈並提高腫瘤控制率降低周邊正常組織病發率。6MV和10MV電腦治療計畫系統單次劑量(理論值)和光激發光劑量計(實驗值)百分標準誤差值為1.25%和1.39%。研究成果可提供臨床放射治療計畫參考及輻射度量工具選擇。

In the radiotherapy of the prostate, the effective dose for its organ at risk in radiation is a great concern of radiation oncologist and medical physicist. In this study, we used the intensity of 6 MV and 10 MV linear accelerator to adjust the intensity-modulated radiation therapy technology to change the treatment angle as well as the volumetric modulated arc therapy technology to change the number of coil to simulate the treatment of patients with prostate cancer. Our study used optically stimulated luminescent dosimeter to measure the intensity-modulated radiation therapy technology and volumetric modulated arc therapy technology on the dose assessment of adjacent organs of prostate cancer. Intensity-modulated radiation therapy technology and volumetric modulated arc therapy technology had similar dose distribution, improved dose distribution, increased tumor control rate and reduce complication rate of the peripheral normal tissue. The standard error of 6 MV and 10 MV computer treatment planning system single dose (theoretical value) and optically stimulated luminescent dosimeter (experimental value) are 1.25% and 1.39%, respectively.