篇名 | Growth Differentiation Factor 15 is Related with Left Ventricular Recovery in Patients with ST-Elevation Myocardial Infarction after Successful Reperfusion by Primary Percutaneous Intervention |
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卷期 | 37:5 |
作者 | Mustafa Umut Somuncu 、 Fatih Pasa Tatar 、 Belma Kalayci 、 Ahmet Avci 、 Naile Eris Gudul 、 Begum Uygur 、 Ali Riza Demir 、 Murat Can |
頁次 | 473-483 |
關鍵字 | Cardiac remodeling 、 Left ventricular function 、 Myocardial infarction 、 Percutaneous coronary revascularization 、 MEDLINE 、 Scopus 、 SCIE |
出刊日期 | 202109 |
DOI | 10.6515/ACS.202109_37(5).20210319A |
Background: The determinants of left ventricular (LV) recovery after successful revascularization in ST-elevation myocardial infarction (STEMI) patients are not clear. In addition, the relationship between growth differentiation factor15 (GDF-15) and left ventricular ejection fraction (LVEF) improvement is also unknown. This study hypothesizes that a low GDF-15 level would be associated with LVEF recovery. Methods: One hundred and sixty-one STEMI patients were included in this study. Echocardiographic examinations were performed before and 12-18 weeks after discharge. The patients were divided into three groups according to the changes in LVEF as 62 patients with 10% change, 47 patients with 1-9% change, and 52 patients 0% change. LV recovery was defined as 10% LVEF improvement and the predictors of LV recovery were investigated. Moreover, two groups were created according to GDF-15 values, and the follow-up/baseline echocardiographic parameters were compared between these groups. Results: LV recovery was detected in 38.5% of the patients. Low baseline LVEF [odds ratio (OR): 0.85, 95% confidence interval (CI) 0.82-0.94, p = 0.001], low GDF-15 (OR: 0.79, 95% CI 0.68-0.93, p = 0.004), previous angina (OR: 2.34, 95% CI 1.10-4.96, p = 0.027), and symptom-to-balloon time (OR: 0.97, 95% CI 0.95-1.00, p = 0.043)were independent predictors of LV recovery. The ratios of follow-up/baseline LV end-diastolic volume index, LV end-systolic volume index and wall motion score index were lower in the low GDF-15 group (0.96 vs. 1.04, p < 0.001; 0.96 vs. 1.10, p < 0.001; 0.89 vs. 0.96, p < 0.001). Moreover, being in the low GDF-15 group was associated with LV recovery (OR: 2.93, 95% CI 1.43-6.02, p = 0.001). Conclusions: Lower GDF-15 level was associated with better LV improvement and less adverse remodeling in STEMI patients.