The building sector has a high level of energy consumption caused mainly by the buildings heating and cooling energy demands to satisfy indoor comfort requirements. Reducing both the amount of energy consumed and the life cycle cost is a main challenge for the construction of buildings. It is evident that sustainable materials have low environmental impacts and need low consumption of energetic resources in addition to their durability and recyclability. Therefore, this research aims to test different sustainable materials available in Egypt for the construction of building envelopes that include local stones “Marble and Limestone” and insulation materials “Polyurethane- expanded and Extruded polystyrene (XPS) foam” in order to achieve savings in energy and total life cycle cost. The simulation tests were conducted through Design Builder software. The results aim to provide solutions for building designers to achieve energy-efficiency and cost-effective design. The proposed alternatives showed a significant reduction in energy consumption by up to 62% and the total life cycle costs significantly reduced by up to 45.8%.