Construction safety is one of the parameters for evaluating the success of a construction project. Evidence from the literature suggests that a poor health and safety (H&S) record is a matter of concern to project stakeholders. The benefits of improved H&S performance include, inter alia, increased productivity, reduced construction cost, reduced workplace accidents, and an enhanced industry image. This research seeks to determine major obstacles to project site safety in Nigeria. An understanding of these impediments provides an opportunity to develop strategies for H&S at construction sites. A questionnaire survey was used to address the objectives of the study, while descriptive statistics were employed to interpret the quantitative data obtained. The findings revealed that stakeholders’ lack of commitment, ineffective H&S regulations, and inadequate H&S training among construction professionals are the major obstacles to H&S performance. This study provides in-depth knowledge by highlighting the significant obstacles to H&S practice. The research is limited to Nigeria and did not secure enough evidence to generalise its findings. Therefore, similar studies are required in other developing countries to compare the impediments to construction H&S in those countries to the findings of this study.