本個案報告為一位罹患未分化型結締組織疾病但無糖尿病病史的老婦人，在服用常用藥物羥氯喹5週後發生長時間且嚴重低血糖的罕見個案。雖然羥氯喹會降低血糖的機轉目前並不十分了解，但是其會發生嚴重且持續很長時間的低血糖須讓我們牢記於心。因此在臨床處方羥氯喹時，臨床醫師需於治療初期檢測病患血糖及執行低血糖衛教。

I report a severe prolonged hypoglycemia side effect of the often-used drug hydroxychloroquine in a non-diabetic elderly woman with undifferentiated connective tissue disease. Although the mechanism of lowering blood glucose levels has not been clarified yet, but severe and prolong hypoglycemia need to be keep in mind. Therefore, in clinical practice, we must be careful when prescribe this drug for patients and check glucose levels in the initial phase. Education on hypoglycemia self-management may also be performed.