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篇名 發展高色準成像系統用於量化及細分尿糖試紙呈色
卷期 231
並列篇名 Quantifying the Glucose Concentration in Urine Test Strip with a Color-calibrated Imaging System
作者 林宇軒李承儒蔡心怡周俊翰黃國政
頁次 108-119
出刊日期 202206

中文摘要

尿液試紙常用於粗略判斷某些疾病的病程,比如腎臟病、糖尿病與肝膽疾病等。其中,糖尿病的病況發展可透過專業的尿糖試紙來初步評估。尿液中過多的葡萄糖會與試紙中的化學物質發生反應,然後呈現出適當的顏色,以供人類觀察和判斷。一般來說,試紙的顏色只能通過目測來判斷尿液中葡萄糖的大致濃度,分析上較粗略並有因人而異的判斷風險;而準確的定量則須仰賴專業的電化學分析設備,但其設備價格高昂(數十萬),檢測時間亦冗長(≥數小時),在便利性上不佳。在這項研究中,我們提出了一種具有顏色校正功能的成像系統來量化尿糖試紙的顏色,其能提升傳統試紙檢測的精密度,成本上亦不致如電化學分析設備般高昂,僅需1/3-1/5硬體成本。本技術透過高演色照明、局部暗室和色彩演算法的組合,來實現色彩偏差小於3的取像色彩準確度,並建立了更適合人類觀察的色彩分佈顯示方法。此外,我們亦發展了色票貢獻分析法,來對尿液中的葡萄糖濃度進行數值性的量化。結果顯示,我們開發的系統可以大大提高尿糖試紙的分辨率。這項研究提供了一種低成本、高品質的檢測概念,未來將可用於家庭醫療診斷和相關的慢性病應用。

英文摘要

Urine test strips are often used to roughly judge the course of certain diseases, such as kidney disease, diabetes, and hepatobiliary disease. Among them, the development of diabetes can be preliminary assessed through commercial urine glucose test strips. Excessive glucose in the urine will react with the chemicals in the test strip, and then show an appropriate color to provide human observation and judgment. Generally speaking, the color of the test strip can only tell the approximate glucose concentration in urine through visual observation. Accurate quantification must rely on professional electrochemical analysis equipment. However, the system is expensive and has a long detection time. In this study, an imaging system with color correction was developed to quantify the color of urine glucose test paper. Through the composition of high color rendering lighting, darkroom barrel and color algorithm, the measurement results successfully achieved color accuracy with a color deviation of less than 3. A color distribution display method that is more suitable for human observation has been successfully established. The method of swatch contribution analysis has also been developed to numerically quantify the glucose concentration in urine. The results show that the developed system can greatly improve the resolution of urine glucose test strip. This research provides a low-cost, high-quality detection concept that can be used for home medical diagnosis and related chronic disease applications.

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