糖尿病心血管疾病包括冠狀動脈疾病及腦中風，本研究之招募對象為2018年期間年滿18歲參加糖尿病健康促進機構，連續收案5,855名糖尿病病人。並將其分為有冠狀動脈疾病與無冠狀動脈疾病的糖尿病病人，以及合併有腦中風與沒有合併腦中風的病人，探討和心血管疾病有關係的風險因子。排除掉資料不全與非第2型糖尿病病人，共5626第2型糖尿病病人，包含307(5.46%)位合併有冠心症的病人，進入冠心症相關風險因子的單變量與多變量羅吉斯分析。在單變量分析中，醫院層級、年齡、性別、教育程度、吸菸、低舒張壓、肌酸酐、總膽固醇、高密度膽固醇、低密度膽固醇、抗血小板用藥、高血壓用藥、高血脂用藥、胰島素、運動時間、疼痛分數等，和冠心症有顯著相關性。多變量分析當中，醫院層級、吸菸、抗血小板用藥、高血壓用藥、胰島素、運動時間，和糖尿病病人是否會併發冠心症有顯著相關聯。共5,625第2型糖尿病病人，包含135(2.4%)位合併有腦中風的病人進入腦中風相關風險因子單變量與多變量分析。在單變量分析中，年齡、教育程度、吸菸、低舒張壓、抗血小板用藥、高血壓用藥、高血脂用藥、胰島素、護理及營養衛教、運動狀況、疼痛分數等，和腦中風有顯著相關。多變量分析校正後，吸菸、抗血小板用藥、高血壓用藥和腦中風有顯著相關。

Cardiovascular disease including coronary artery disease and stroke are the first leading cause of death in the world. Global evaluated the risk factors on cardiovascular disease among type 2 diabetes mellitus were well demonstrated, but the association evidence among Asian population was lack. The cross-sectional Diabetes Health Promotion Institutions (DHPI) study were conducted to evaluate the association among risk factors and coronary artery disease and stroke in type 2 diabetes mellitus patients in Taiwan. Of 5626 type 2 diabetes mellitus patients were included (mean age 64 years old), 307(5.46%) had coronary artery disease. Coronary artery diseases were significantly associated with hospital level, age, sex, education level, smoking, diastolic blood pressure, creatinine, total cholesterol, low-density lipoprotein, antiplatelet drugs, hypertension drugs, hyperlipidemia drugs, insulin medication, exercise duration, Douleur neuropathique 4 score were significantly associated with cardiovascular disease. After adjusted multivariate, coronary artery diseases were significantly associated with hospital level, smoking, antiplatelet drug, hypertension drug, insulin, exercise duration. Among all type 2 diabetes, 135(2.4%) stroke was identified. Stroke was significantly associated with sex, education level, smoking, diastolic blood pressure, antiplatelet drug, hypertension drug, hyperlipidemia drugs, insulin used, health education, exercise duration and neuropathy. After adjusted multivariate, stroke was significantly associated with smoking, antiplatelet drug and hypertension drug. The study identified the risk factors for coronary heart disease in Taiwanese type 2 diabetes patients include old age, smoking, physical activity, peripheral neuropathy, antiplatelet therapy, hypertension medication, insulin use, hospital level, and low education level. The risk factors associated with stroke were old age, smoking, physical activity, peripheral neuropathy, nursing and nutrition education status, antiplatelet therapy, hypertension medication, low diastolic blood pressure, insulin use, and low education level. Further investigation is warranted to understand the mechanisms underlying these associations.