隨著年齡老化，人體骨質流失造成骨質疏鬆症，導致骨折的危險性增加，影響生活品質甚鉅。體能運動與骨質疏鬆的關係密切，許多研究曾提出運動量不足和骨質疏鬆的相關性。本研究透過台灣人體生物資料庫所收集的大規模臺灣社區民眾健康資料，包括個人基本資料、生活型態及運動習慣調查、骨質密度與其他身體檢查數值，利用量化的方式計算參與者的運動量，並加以分組，試圖分析運動量與骨質疏鬆風險的相關性。本研究發現，40歲以上成年人達到世界衛生組織所建議的「每週150分鐘以上的中高強度運動」，相對於沒有運動習慣的族群，有較低的骨質疏鬆風險。

Objectives: To investigate the association of physical exercise amount and osteoporosis among community-dwelling adults from Taiwan Biobank. Material and Methods: This retrospective cross-sectional study recruited people aged 40 years and older who attended a personal data and lifestyle survey, diet and exercise questionnaire, body checkup and bone density examination in Taiwan Biobank during 2012 to 2019. Participants’ monthly physical exercise amount was categorized into non-, light, moderate and vigorous levels. Bone mineral density (BMD) was measured by quantitative ultrasound. Osteoporosis was defined according to the World Health Organization as BMD T-score less than or equal to - 2.5. Multiple logistic regression analysis was applied to determine independent factors associated with osteoporosis. Results: Among 79617 participants recruited for this study, 36491(45.8%) had regular exercise habit, and 9108(11.4%) were diagnosed with osteoporosis. After adjusting for monthly exercise amount, age, sex, education level, marital status, place of residence, current smoking status, body mass index, waist circumference, and body fat percentage, we found moderate and vigorous physical exercise amount remained at a significant level for lower risk of osteoporosis (OR: 0.82; 95% CI: 0.77-0.88; P < .001 and OR: 0.68; 95% CI: 0.64-0.72; P < .001) in multiple logistic regression. Conclusions: Moderate and vigorous monthly physical exercise amount was associated with lower osteoporosis risk among community-dwelling adult.