The uniqueness and scarcity conferred by blockchain to NFTs provide new digital marketing channels for brands. Many brands and artists are trying to sell or operate their own NFTs in order to establish their influence in the digital world. However, there is currently a lack of research on NFT brand marketing in the market, and there are few relevant case studies. This study analyzes the three processes in which Takashi Murakami participated in NFT sales, including the 108 Murakami Flowers series, Clone-X series, and Murakami Flowers 2022 series. It combines brand, NFT market, and related marketing strategy theories to describe how traditional artists formulate their marketing strategies and establish brand awareness in the NFT market from a case study perspective. The research results show that using brand marketing and combining with the operating mode of the market can effectively help brands or artists expand their influence in a new field and achieve significant brand marketing effects.