陽離子交換樹脂（Cation exchange resin），常用於慢性腎臟病（Chronic kidney disease）病人高血鉀（Hyperkalemia）之治療，常見的副作用包括噁心、食慾不振、便秘、低血鉀等，然而使用該類型藥物亦有罕見且嚴重之腸胃道不良反應的風險。本文將透過文獻回顧探討陽離子交換樹脂相關嚴重腸胃道不良反應之致病機轉、不良反應相關性與處置方式，以期提醒醫護人員於使用陽離子交換樹脂治療期間隨時留意病人臨床狀況，確保病人之用藥安全。

Cation exchange resin is often used to treat hyperkalemia in patients with chronic kidney disease. Common side effects include nausea, loss of appetite, constipation, hypokalemia, etc. However, the use of this type of drug also carries a risk of rare but serious gastrointestinal side effects. This article discusses the pathogenesis, correlation and treatment of serious gastrointestinal adverse reactions associated with cation exchange resins through a literature review, in order to remind medical staff to pay attention to the clinical status of patients during treatment with cation exchange resins and to ensure the patient's medication safety.