2014年公布十二年國民教育課程綱要總綱後，我國於108學年度開始執行（故稱108課綱），本項教育改革高中端改變幅度最大，也考驗校長課程與教學領導的智慧。本研究以一所普通高中為研究場域，藉由訪談與文件分析的方式蒐集資料，主要在瞭解個案學校校長運用課程與教學領導推動108課綱之歷程、成功經驗、困境與相關解決策略，並評析個案校長公開授課成效。最後歸納出個案學校前後任校長均為正向108課綱倡導者；學校推展108課綱時面臨部分難題，然校長能提出因應策略；校長能落實公開授課，促進學校課程與教學品質的提升之研究結論，並據此提出建議。

After the Curriculum Guidelines of 12-year Basic Education was announced in 2014, Taiwan began to implement these new guidelines in the 108 academic year (titled as 2019 Guidelines). Since then, the general senior high schools have encountered the most challenges upon this reform, which also did verify the professional skills of all principals' curriculum and instructional leadership. This study, taking a general high school as the research base, and collected related data through interviews with the principal and document analysis, with a purpose to further understand the processes how the principal used his leadership, specifically on the curriculum and instructional perspectives, to promote this 2019 Guidelines. This research also looked at the success and difficulties the principal faced and how he dealt with them. The effect of his open classes was explored, too. Finally, the results found were that the positive manner on the Guidelines was both supportively implemented by the two principals of the school, the former and later ones. Through various strategies of curriculum and instructional leadership applied, the overall quality of the school's curriculum and teaching was greatly improved. Though the school did face some difficulties in promoting the Guidelines, the later principal was able to propose some research conclusions as well as several corresponding strategies to address them. As a conclusion, this paper also made some suggestions for possible studies in the future.