腦膜瘤和膠質母細胞瘤有截然不同之病理生理學特徵。先前曾切除過腦膜瘤且沒有經歷過放療等誘發因素的新生成膠質母細胞瘤在過往文獻很少見，對於其成因或危險因子目前沒有定論。我們報告了一名78歲男性，他被診斷出患有腦膜瘤，十三年前接受腫瘤切除術並在追蹤期間保持穩定且無輔助放療。本次入院主訴為近期出現雙下肢肌無力，頭痛和口齒不清。在先前切除的腦膜瘤位置附近發現右側顳葉顱內腫塊。最終病理報告確診為膠質母細胞瘤。本例可能是巧合的結果，或支持先前文獻認為腦實質損傷與高級別膠質瘤形成有因果關係。

Cases introduced glioblastoma arises from previously resected meningioma without inducing factors are rare. We reported a 78-year-old male who was diagnosed with meningothelial meningioma, underwent tumor excision and remained stable during out-patient department follow up without adjuvant radiotherapy administrated 13 years ago before this admission. An intracranial mass lesion in right temporal lobe was found around the location of previous resected meningioma. Final pathology report confirmed a diagnosis of glioblastoma. This case may be a result of coincidence or supports previous hypothesis of the relationship between parenchymal injury and high-grade glioma formation.