從1988到1990年，共有36位陽萎的病人在接受外科手術治療中同時接受陰莖海綿體切片檢查，另外以31位來自其它疾病非陽萎的病人或屍體的陰莖組織作對照，發現陽萎病人的陰莖海綿體組織呈現各種不同程度的纖維化變化，即平滑肌漸漸退化，結缔組織增生與沈澱，陰莖海綿體內小樑的結構和海綿竇的上皮細胞被破壞。陽萎病人和其他成人標本之間，陰莖海綿體纖維化的程度，統計學上分析並沒有顯著地差別，並且這些非特異性組織學上的變化，並不能決定或區分各種可能造成陽萎的致病因子，只能建議若術前陰莖組織切片檢查呈現中等或嚴重程度纖維化時，可能不必要嘗試採用陰莖血管重建手術或靜脈結紮手術，至於陰莖海綿體切片檢查在選擇治療病人的策略，其所佔的角色，仍需進一步地研究、證實。

From 1988 to 1990, thirty-six patients were received penile biopsies during the surgical treatments for impotence. Meanwhile, 31 samples were taken from 9 potent patients and 22 cadavers for comparison. Various degree of fibrotic changes of corpora cavernosa were found in impotent penile tissues.i.e. There were degeneration of smooth muscle bundles, increased deposition of collagen fibers and distorted architecture of trabeculae. Moreover, the endothelial lining of sinusoid might be destroyed later. No statistically significant difference in the degree of fibrotic changes was found between the impotent and the 21 controlled adult patients. Different etiologies of impotence al-socould not be determined by these nonspecific histological changes. We recommended that if the histopathologic findings of pre-operative biopsy of corpora cavernosa demon-strated moderate to severe fibrotic change, it would not be necessary to arrange penile revascularization or venous ligation. However, the role of the intracorporeal biopsy in determining the therapeutic option still need further study for verification. (J Urol R.O.C., 2:457-464, 1991)