簡介：瘧疾是由瘧原蟲感染紅血球所造成。特別是”非免疫旅行者”有嚴重瘧疾的高風險。旅行者在可能接觸暴露的3個月內發熱，應立即調查是否有瘧疾。病例報告：我們提出了一個病例分析，一位從瘧疾流行地區回來的攝影師，快速進展為熱帶瘧原蟲的惡性瘧疾，伴有高燒，意識改變和嚴重的黃疸。病情進展成敗血症並且惡化迅速，當下重症加護治療立即開始，患者在用青蒿素治療後完全恢復。個案報告後介紹瘧疾的診斷和治療。結論：由於職業原因旅行至疫區，回國後有發燒的人應盡速診斷及治療瘧疾。目前青蒿素是嚴重瘧疾的首選藥物。藉由適當的重症加護照顧，嚴重瘧疾的患者可以很好地康復。

Introduction: Malaria is caused by protozoan parasites Plasmodium that infected red blood cells. Non-immune travelers are particularly at high risk for severe malaria. Fever in a traveler within 3 months of possible exposure should prompt immediate investigation of the disease. Case reports: We presented a case who is a photographer traveled back from malaria endemic area and developed severe malaria with the presentation of high fever, consciousness change and severe jaundice. The sepsis developed and deteriorated rapidly, the intensive care therapy started immediately. The patient was fully recovered under treatment with Artesunate. The presentation, diagnosis, and treatment guidelines were discussed. Conclusion: People with fever and relevant epidemiologic exposure due to occupational reasons should workup for malaria immediately. Currently parenteral artesunate is the drug of choice for severe malaria. With adequate intensive care, patients with severe malaria could be recovered well.