巨細胞病毒（CMV）是在人類中普遍存在。在正常免疫力的人通常是無症狀的。但是，它可導致慢性腎病患者產生嚴重症狀。巨細胞病毒會導致在多種臨床表現，包括許多非特異性表現（包括發熱，不適，關節痛，白細胞減少，和血小板減少症）和影響到各個器官。在慢性腎病患者，巨細胞病毒經常影響到胃腸道，並產生顯著死亡率。我們報告一例55歲男性，為糖尿病合併末期腎病。因多處傷口感染合併有敗血症而住院。使用經驗性抗生素和執行傷口清創，病情改善。但發生突發性大量胃腸道出血。胃鏡和大腸鏡檢查並未發現明顯的出血點。血管造影顯示在空腸遠端活動性出血。由於大量出血，外科手術被執行，剖腹探查和切除出血空腸和迴腸（共300條厘米）。切除空腸和迴腸的病理報告顯示巨細胞病毒感染引起的潰瘍和慢性腸炎。巨細胞病毒性腸炎可能會危及生命。在末期腎病病人的巨細胞病毒性腸炎常是診斷不足的。所以醫師應在末期腎病病人意識到這一點，以免延誤病情。

Cytomegalovirus(CMV) is ubiquitous in humans. It generally produces asymptomatic in the immunocompetent host, however, it can result in severe symptoms in chronic renal failure patients. It can result in a variety of clinical presentations, including a nonspecific syndrome (which may include fever, malaise, arthralgia, leukopenia, and/or thrombocytopenia in the setting of viremia) and end-organ disease. The gastro-intestinal tract is frequently involved in renal failure patients and is associated with significant mortality. We report a case of 55-years-old male patient admitted to medical intensive care unit with sepsis due to multiple wounds infection. During hospitalization massive gastrointestinal bleeding developed. Upper GI panendoscopy and colonoscope could not show bleeding sites. Angiography revealed active bleeding over distal jejunum. Explorative laparotomy and resection of bleeding jejunum and ileum (total 300 cm) was done. Pathological report of resection of jejunum and ileum revealed ulcer with CMV infection and diffuse chronic enteritis. Cytomegalovirus enteritis is life-threatening. CMV enteritis may be under-diagnosed in critically ill patients with renal failure. So physicians should be aware of it in renal failure patients.