We present a case of a 66-year-old woman who visited our hospital on account of acute renal failure combined with vesical stones and ureteral stone due to uterine prolapse. An emergency percutaneous nephrostomy was performed, and supportive treatment was administered. On the 5th day post-hospitalization, the renal function of the patient had recovered to a normal range. Then cystoscopy, ureteroscopy, and electrohydraulic lithotripsy were performed to remove the vesical stones and ureteral stone. Finally we consulted a gynecologist to perform a vaginal hysterectomy together with anterior and posterior colporraphy, and culdoplasty to treat the uterine prolapse. The patient was discharged in a stable condition. Since then, the patient has visited our outpatient department regularly, and no more acute renal failure or urolithiasis have been noted. We report this case and review the literature.