Peyronie's disease involves uncontrolled tissue fibrosis within the tunica albuginea. Trauma has been cited as its cause. Injury causes inflammatory reactions, leading to excessive fibrin deposits and distorted elastic fibers within the tunica albuginea. When acute, typical symptoms and signs begin with the incidental discovery of dorsal penile indurations with tenderness during erection. Pain usually subsides after 3~6 months, but the induration can last 6~12 months. In the later stage, penile curvature during erection follows if the induration or fibrotic plaque becomes extensive. Peyronie's disease is closely associated with erectile dysfunction and shares the same comorbidities. A diagnosis of Peyronie's disease depends on careful history-taking and a physical examination. The plaque size and location, as well as the quality of erections and severity of curvature should be evaluated and recorded. Penile ultrasonography (US) is helpful for objective plaque localization and measurement. Duplex US with intracorporeal injection of vasodilators is indicated to define the deformity and evaluate hemodynamic changes. Initial treatment should include explanation of the disease and possible treatments. Nonsurgical treatments are indicated in the early stages with minimal or mild deformity. Surgical treatments include plication with or without plaque excision, graft reconstruction, and penile prosthesis implantation. Plication surgery is indicated in patients with nontender, stable plaques (>6 months), minimal to mild curvature (30°~60°), and adequate erectile rigidity (with or without pharmacological treatment). In potent patients with extensive or complicated deformities and moderate to severe curvature, the fibrotic tunica albuginea can be reconstructed by a graft with an incision or excision of the plaque. Penile prosthesis implantation should only be considered and carried out in patients with complicated deformities and severe erectile dysfunction.