從1986到1996年，六位患有外生殖器乳房外paget氏疾病的男性病人在本院接受治療。平均年齡為七十一歲(62-83)，其患部在陰莖處有一位，會陰及陰囊者有兩位，陰莖及陰囊者有三位。由發病至確立診斷，其平均時間為三年(0.5-10)，六位病人均無其它內在惡性疾病，但合併潹巴轉移者有兩位。所有病人都接受廣範性病兆切除及冰陳切片檢查，兩位合併淋巴轉移者並接受輔助性放射治療，在追蹤過程中，一位死於鬱血性心衰竭，一位於手術三年後有局部復發情形，其餘病人皆無復發跡象。乳房外Paget氏疾病是一種罕見的表淺惡性疾病，而其常被誤認為慢性溼疹或接觸性皮膚炎而延誤診斷，對誕些病兆唯有早期切片檢查方為最佳的診斷方法，廣範性的病兆切除並確立切口邊緣未被腫瘤侵犯是最好的治療方式，放射治療可作為淋巴轉移者之輔助治療，化學治療一般並不需要且對末期患者效果極差，因局部復發情形常可見，所以對於此種病人必須加以嚴密而確實的追蹤檢查。

From 1986 to 1996, six male patients with extramammary pagest’s disease (EMPD) over external genitalia were treated at TSGH. The mean age was 71 years (range, 62-83). The tumors were located in the penis in 1 patients, perineum and scrotum in 2 patients, penis and scrotum in 3 patient. The average disease course before diagnosis was 3 years (range, 0.5-10). Histopathol-ogy showed EMPD alone in 4 patients and EMPD with lymph node metastases in 2 patients. All patients received wide excision and frozen section during operation. Two patients received ad-junctive radiotherapy for lymph node metastases. During follow-up period, one patient died of congestive heart failure 6 months after diagnosis. One patient with tumor recurrence received wide excision again about 3 years later. The other four patients were free from tumor recurrence during follow-up period. Extramammary Paget’s disease is a rare cutaneous malignancy, which is easily mistaken for chronic eczema or contact dermatitis and leads to delay in the diagnosis. Only early biopsy for those obstinate skin lesion is the optimal method for diagnosis. Wide exci-sion with adequate free margins is the recommended treatment. Radiotherapy is used as adiunc-tive treatment for those patients with lymph node metastases. Combined chemotherapy is usually unnecessary and has poor response to far advanced cases. Local recurrence is common. Close follow-up is necessary in all patients with this pathologic entity. (J Urol R.O.C., 8:191-196,1997)