神經節神經母細胞瘤是一種源自神經塉的腫瘤，其形態及病程表現是介於神經母細胞瘤和神經節神經細胞瘤。其發生頻率約為神經母細胞瘤的五分之一，而且一半的病人是十四歲以下。從民國七十二年到八十四年，三軍總醫院共有兩位神經節神經母細胞瘤的病人並接受手術及後續化學和放射治療。其中一例在第一次術後四十四個月內共發生三次腹膜內不同位置的轉移，這四次手術標本的細胞去氧核醣核酸流動分析圖及細胞組織型態皆非常相似，可輔助推斷是同一種幹細胞衍生而來。在此我們提出這個病例，並做文獻回顧。

Ganglioneuroblo.stoma originates from neural crest tissue; it is the intermediate type between mature neuroblastoma to ganglioneuroma. Its frequency is about one-fifth that of the neuroblastoma, with half of the cases is younger than 14 years of age. From 1983 to 1995, two ganglioneuroblastomas were diagnosed by pathology at Tri-Service General Hospital. One of the two cases had tumor recurrence three times postoperatively during a 44-month follow-up period. In addition to similar histopathological features, DNA flow cytometric analysis revealed the same DNA stemlines in tumor specimens from different locations. This indicates that these metachronous tumors could be a serial peritoneal implantations of tumor cells from the original huge retroperitoneal tumor. Multicentricity of different stem lines is unlikely in this case. Extraperitoneal radical excision of the tumor and delicate manipulation to prevent intraperitoneal seeding is advised.