全氟辛酸（PFOA）因為具有防油及防水特性，為許多消費物品及食品
接觸物件的關鍵化學物質。在各種廣泛的環境介質中，PFOA已達到需被關
注的偵測濃度。本研究探討在高溫油及調味料（鹽、醬油、醋、蕃茄醬）的
傳統中國式烹調條件下，不沾鍋（125°C）及防油紙（100°C）PFOA的遷移
濃度。若與僅使用高溫油的試驗比較，本研究發現，添加各種含有離子調
味料的高溫油烹煮會促進PFOA的遷移，不沾鍋最高可達1.2 ng/dm2
，防油
紙最高可達9.2 ng/dm2
。本研究進一步使用美國食品藥物管理局（USFDA）
建議之累積日攝取限值（Cumulative estimated daily intake, CEDI）及暴露
情境（表面接觸係數155 g/dm2
、攝食量3 kg/d 、體重60 kg） ，使用確定法
（Deterministic approach），推估高暴露族群（攝食比0.8）及一般暴露族群
（攝食比0.4）之法規限值，結果分別為25及50 ng/dm2
。

The antipsychotic drug “haloperidol” (HAL) has been widely used for the treatment of a range of neuropsychiatric disorders. However
treatment also induces extrapyramidal symptoms (EPS) including short term parkinsonism and late complication tardive dyskinesia (TD).
These idiopathic symptoms are associated with serious limitations in this therapy. Some studies have suggested that oxidative stress induced
during the metabolism of HAL is involved in the elicitation of EPS. We speculated if green tea may prevent HAL-induced EPS because
of its antioxidant properties. In the present study, the efficacy of green tea extract (GTE) given as a sole source of water on HAL-induced
EPS male albino wistar rats was examined. We found that HAL-induced motor deficits and elicitation of TD were more severe in GTE
than water dinking animals. HAL-induced dopamine level was increased and its metabolites concentrations were higher in the nucleus
accumbens and lower (p < 0.01) in the caudate of GTE-drinking than water-drinking animals. Increased ratios of homovanillic acid (HVA)
and 3, 4-dihydroxyphenylacetic acid (DOPAC)/dopamine in the caudate may be involved in the precipitation of HAL-elicited EPS while
drinking GTE. Conversely GTE increased the level of dopamine moreover raised its metabolites in the nucleus accumbens may relapsed
the schizophrenic symptoms while on the treatment HAL. We thus suggest that patients on HAL therapy should avoid green tea.