背景：在臨床經驗中，混合感染沙門氏菌和輪狀病毒偶爾可見。但是對於這方面的研究報告極少。所以我們就來討論混合感染，與單獨感染沙門氏菌貨輪狀病毒，在症狀上或實驗數據上有何不同。方法：我們共收集了391 為罹患腸胃炎的病童。糞便檢體在住院當中收集，並同時執行細菌培養與倫撞病毒抗原檢查。其中8 位病童為混合感染，我們將其與感染沙門氏菌及輪狀病毒腸胃炎比較，統整後並加以分析。結果：8 為混合感染的病童分別在2006 年七月、八月及2007 年四月、五月、九月住院。住院時間自2 日至10 日。病童的年紀由6 各月大至5 歲3 各月大(平均2.8 歲)。發燒時間自2 天置7 天。沙門氏菌菌種包括：B 型沙門氏菌(n=5)、D 型沙門氏菌(n=2)、C 型沙門氏菌(n=1)。混合感染的病童同時有嘔吐、水瀉，糞便中並有黏液及血絲。比較混合感染與沙門氏菌及輪狀病毒腸胃炎的C-反應蛋白(CRP，C-Reactive Protein) ，單獨沙門氏菌的指數為最高，輪狀病毒腸胃炎的指數為最低。結論：在此研究中，混合感染的症狀與輪狀病毒腸胃炎的症狀明顯不同。症狀與沙門氏菌腸胃炎類似，但是C-反應蛋白(CRP，C-Reactive Protein) 較低。

Background and purpose: The objective of this study was to describe the clinical presentation of mixed infections in the gastrointestinal tract of children. There are only a few reports discussing the characteristics of mixed infection with Salmonella enterocolitis and rotavirus gastroenteritis. Methods: The study population consisted of 391 children who were seen in the Pediatrics Department of Cathay General Hospital, Taipei, Taiwan, for acute gastroenterocolitis. Fecal specimens were collected at admission, and a rotavirus antigen was detected at that time. Eight patients were found to have mixed infection with both Salmonella and a rotavirus. Results: Eight patients(6 boys and 2 girls), who were infected by both Salmonella and a rotavirus, were admitted during July and August 2006 and April, May, and September 2007. The hospital stay ranged 2~10 days. The admitted patients ranged in age from 6 months to 5 years, 3 months (mean, 2.8 years). The fever course ranged 2~7 days. The Salmonella species were as follows: Salmonella group B(n = 5), Salmonella group D (n = 2), and Salmonella group C2 (n = 1). Patients who had mixed infection with both Salmonella and a rotavirus had more vomiting and watery diarrhea as well as stools containing blood and mucus. In a comparison of the C-reactive protein value between the 3 groups, the value was highest in the pure Salmonella-infected group, and lowest in the pure rotavirus-infected group. Conclusions: In this study, symptoms of mixed infection were similar to those of Salmonella enterocolitis, and significantly differed from those of rotavirus gastroenteritis. The mixed infection produced the same symptoms as that of Salmonella spp., except that the CRP level was relatively lower.