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中華民國泌尿科醫學會雜誌
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| 篇名 | Transplantation of Human Transitional Cell Carcinoma in the Nude Mouse Bladder: Comparison between Electrically and Chemically Injured Urothelium |
|---|---|
| 卷期 | 1:1 |
| 並列篇名 | 裸鼠膀胱內種植人類移形上皮細胞癌之研究：電燒及化學處理膀胱上皮模式之比較 |
| 作者 | 馬正平 、 于大維 、 張聖原 、 葉明陽 、 韓韶華 |
| 頁次 | 5-10 |
| 關鍵字 | transitional cell carcinoma 、 unde mouse bladder 、 chemically injured urothelium 、 electrically injured urothelium 、 electrically injured urothelium 、 TSCI |
| 出刊日期 | 199003 |
中文摘要
利用電燒及化學處理裸鼠膀胱上皮後，吾可成功的將人類膀胱癌細胞株（TSGH-8301）種植生長於其膀胱內。接受化學處理之裸鼠其死亡率（60%）較之經電燒處理者為高（20%）。但經電燒處理之裸鼠其腫瘤之接受率為63%，較之經化學處理者（25%）及未經任何處理之對照組（10%）為高。此成功之動物腫瘤移植模式可提供吾人日後對膀胱癌更理想之研究。
英文摘要
Human transitional cell carcinoma was successfully transplanted and established into the bladder of nude mouse via techniques of electrically or chemically (N-nitro-N-methyl urea) injured urothelium with instillation of tumor cells from a human bladder cancer cell line TSGH-8301. The mice with chemically injured urothelium had higher mortality (60% vs 20%) and morbidity rate than mice with electrically treated urothelium. Tumor taking rate was much higher in the lelctrically treated mice (63%) than chemically treated mice (25%) and control group (10%). This model makes animal studies for human bladder cancer possible and more physiological.